LOOP-IT
by neuroConn Technologies
all-in-one solution that sets new standards in neuroscience lab equipment
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LOOP-IT enables state-dependent and closed-loop controlled experiments without prediction, Temporal Interference Stimulation and neuromuscular stimulation – all simultaneously and synchronously and within one box.
The simultaneous application of non-invasive brain stimulation (NIBS) and EEG has significantly advanced our comprehension of NIBS-induced local and network effects, as well as the functional role of brain oscillations. The manipulation of individual parameters, such as intensity, frequency, and phase, can influence the outcomes of NIBS. State-dependent NIBS allows researchers to precisely control these parameters and influence brain activity with high temporal and spectral precision.
The system ensures minimized constant delays between data acquisition, analysis, event detection, and derived parameters for the output module (e.g., tES or FES current source, trigger of TMS).
Functioning as a multi-channel stimulator for 2 or 4 transcranial and / or peripheral stimulations, our current sources exhibit low noise, high temporal precision, and galvanic isolation. This setup is specifically designed for temporal interference stimulation as well as pairing transcranial and neuromuscular stimulation, providing a comprehensive solution for advanced neuroscience research.
Features
Galvanically ilsolated modules with different functionality:
- EEG / ECG / EMG biosignal acquisition (up to 1 ksps)
- tDCS / tACS / tRNS current sources (low 1/f noise, < 5 mApp,
< 5 kHz bandwidth) - neuromuscular electrical stimulation (NMES) (< 200 kHz, full scale rise time: 1 µs; high-power (+/- 40 mA) and high speed application up to 1 ms duration in constant current applications (+/- 15 mA)
- multichannel digital I/O interface (e. g. TMS, event-related potentials)
- additional sensor interfaces for non-electrical biosignals (e. g. movement, breathing, blood flow, temperature)
Real-time system for physiological oscillation phase-dependent stimulation:
We provide a system enabling state-dependent and closed-loop controlled experiments in a stable time regimen with 1 - 3 ms turn-around time:
- data acquisition of ExG (EEG, ECG, EMG), 3-axis acceleration 24 bit / 1 kHz
- data analysis of amplitude, frequency, latency, phase
- modulation and control of the actuators tES / NMES / TMS
Direct access to hardware parameters via supplied library (Python)
Medical-grade hardware design
Standard interface and compact design
Applications
Conventional applications on TMS
- Collecting EMG for MEP investigations during TMS for read out on M1
- Collecting ECG for HR investigations during TMS for read out on DLPFC
- Collecting EEG for TEPP investigations during TMS for read out on the whole brain
EEG & NIBS (8x EEG, 1x DIO)
- towards personalised therapeutic brain-state dependent therapies in rehabilitation and psychiatry
NIBS (2x tES)
- Temporal interference stimulation for enabling targeted structures deep inside the brain by steering the electric fields of maximum amplitude modulation
NIBS & NMES (1x tES, 1x NMES)
- Phase-dependent modulation of human corticospinal plasticity by associative pairing of transcranial and neuromuscular stimulation (tES & NMES)
Product infos for download
Accessories
We offer a wide range of accessories for EEG acquisition and tES application, including electrodes of various dimensions and shapes, cables, caps and conduction pastes. Products can be ordered individually or in a set. We will also be happy to advise you which electrodes are best suited for your project.
Get in touch
Our highly experienced engineers are available to discuss your research or lab requirements for closed-loop, neurostimulation and multimodal neuromodulation solutions.