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Brainsight TMS

for MRI-based TMS Neuronavigation

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Application
Specifications
Integration with EEG imaging

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In transcranial magnetic stimulation (TMS), a pulsating magnetic field affects the electrical activity of nerve cells in the brain.

This requires precise positioning of the magnetic coil over the region to be stimulated in the brain. In TMS studies, the coil is positioned over the head using external landmarks and measurements or by trial and error until the desired response (finger twitch for example) is generated.

The Brainsight® TMS neuronavigation system by neurocare partner Rogue Research Inc. offers an alternate function: the technology visualizes the client's brain based on MRI data sets in order to move the coil to the desired brain structure and correctly position it.

In current joint development efforts neuroConn GmbH and Rogue Research aim to:

  • optimize data exchange between LOOP-IT and Brainsight® TMS systems, facilitating real-time closed-loop applications in neuroscience research

  • allow stimulation targeting via electric field modelling for TMS and current flow modelling for tES

 

Application

In traditional TMS studies the coil is positioned over the head using external landmarks and measurements or by trial and error until the desired response (finger twitch for example) is generated. However, in recent years and with the improvement of stereotactic techniques, navigated TMS or Neuronavigation is now possible allowing the TMS coil to be navigated and positioned over a specified target location based upon an individual's MRI image or MRI generated 3D curvilinear reconstruction of the brain. Targets for stimulation can then be identified in numerous ways:

  • manually by selecting and highlighting the desired structure / locations within the brain, or
  • by combining anatomical MRI images with areas of activity highlighted with fMRI, EEG or NIRS.
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Brainsight TMS
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Specification of the Brainsight® TMS Navigation

Definition of targets using either: Anatomy / MNI- or Talairach co-ordinates / MRI overlays (fMRI, EEG, NIRS, PET) / Data aquired from previous TMS sessions
Electric field modelling for TMS and/or current flow modelling for tES integrated via SimNIBS
Compatible with all widely used MRI datasets including: DICOM, PAR/REC, Analyze, NIfTI, MINC, BrainVoyager (VMR und VMP)
Directly links to TMS devices via TTL trigger and/or serial port
Integrated 2-channel EMG for mapping studies
Multi-channel EMG mapping via NEURO PRAX® TMS/tES or LOOP-IT
For each TMS pulse delivered Brainsight® TMS can record: Coil position and orientation / Coil status (with supported TMS devices) / Intended target / Positioning error / Distance to target / EMG response / heart rate response / EEG response when combined with NEURO PRAX® TMS/tES / LOOP-IT / NIRS response when combined with Brainsight NIRS
Easy export of recorded data
Track multiple tools (e.g. multiple TMS coils)
New and improved subject chair to help position the subject comfortably and accurately with the added advantage of holding TMS coil(s)

Integration with LOOP-IT

Learn more about LOOP-IT

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In a joint development funded by the German and Canadian government (ZIM, BMWE, NRC IRAP) neuroConn GmbH and Rogue Research aim to optimize data exchange between LOOP-IT and Brainsight® TMS systems, facilitating real-time closed-loop applications with TMS and tES.
Stimulation targeting via electric field modelling for TMS and current flow modelling for tES: Integrated support for the SimNIBS current modelling software - allows to use SimNIBS in Navigation Workflow to add realistic E-field modelling to the target selection process in TMS and tES.

Integration with NEURO PRAX® TMS/tES

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NEURO PRAX® TMS/tES automatically detects and connects to Brainsight® TMS via WLAN.
Transfer and display of EEG montages within Brainsight space
Use Brainsight to digitise and record EEG electrode positioning.
Transfer EEG data automatically for each TMS pulse trigger.
View EEG data as a list or in a 3D curvilinear view.
Easy export of data to preferred EEG analysis software.
Import results into Brainsight for visualisation.

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Axilum TMS-Robot

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France-based Axilum Robotics have developed an innovative system that allows for accurate and safe placement, tracking and recording of a TMS stimulating coil during a TMS experiment or treatment session, together with the Brainsight TMS Navigation system.

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